The doctrine of Divine Transcendence (Tanzih) is a fundamental Qur’anic concept, explicitly stated in verse 42:11: “There is nothing like unto Him.” While traditionally analyzed through creedal doctrines and the negation of anthropomorphism (Nafi al-Tashbih), its ethical dimensions remain under-explored. This study investigates how Tanzih shapes human attitudes and virtues. Using a descriptive-analytical method based on the exegesis of the aforementioned verse, the research elucidates the link between Tanzih and ethical transformation. The theoretical framework posits that by negating likeness between Creator and created, Tanzih prevents humans from absolutizing their understanding, facilitating a reconstruction of self-concept. The findings suggest that a transformation in human self-understanding paves the way for the formation of a set of moral virtues in both theoretical and practical dimensions. Epistemic humility in grasping the truth, the negation of self-centeredness and arrogance (istikbār), and the avoidance of anthropomorphism in conceiving the Divine are among the implications of the theoretical dimension. Furthermore, the reinforcement of servitude ('ubudiyyah) and sincerity (ikhlas), alongside moral responsibility in religious judgment and discourse, are considered implications of the practical dimension of the principle of tanzīh (transcendence).Findings indicate that this shift fosters virtues such as epistemic humility, the rejection of self-sufficiency and arrogance (Istikbar), the strengthening of servitude (Ubudiya) and sincerity, moral responsibility in religious discourse, and the avoidance of anthropocentrism in understanding God. Ultimately, the Qur’anic doctrine of Tanzih provides a foundation for religious ethics grounded in humility, epistemic responsibility, and the avoidance of human absolutism.